太阳集团2138登录入口

1998-2002：兰州大学太阳集团2138登录入口，学士

2005-2010：兰州大学太阳集团2138登录入口，博士（导师：涂永强院士）

2002-2010：兰州大学功能有机分子化学国家重点实验室

2010-2011：美国芝加哥大学 (The University of Chicago) 化学系，博士后（导师：何川教授）

2011-2014：美国宾夕法尼亚州立大学 (Penn State University) 化学系，博士后（导师：陈弓教授）

2015-2020：太阳集团2138登录入口，特别研究员（长聘教轨副教授）

2021-2022：太阳集团2138登录入口，长聘副教授，院长助理

2022-至今： 太阳集团2138登录入口，教授，副院长

以合成化学为基础和核心的多学科交叉研究。

1）合成方法学：活性C-H键多位点选择性调控与惰性C-H键活化反应研究；

2）全合成化学：以C-H键选择性反应为核心的天然产物及药物分子的集体全合成；

3）功能分子创制：结合计算和机器学习的NIR II 荧光探针，CPL 探针，先进光刻材料。

感谢国家新药重大专项、科技部重点研发计划、国自然科学基金、上海市科委、上海市教委、上海交通大学及海外青年人才项目经费支持！

近期代表性论文：

1) Electrochemical Enzyme-Mimetic Radical Cascade Cyclization of Polyenal: Collective Syntheses of Clerodane Diterpenes and Sesquiterpene (Hydro)quinones

Liqun Yang, Jun-Chen Kang, Shen-Yuan Zhang, Hao-Tian Zhang, Ru-Xin Liu, Shuo-Shuo Liu, Cheng-Wei Yuan, Xin-Yu Chen, Si-Hua Hou and Shu-Yu Zhang*

Nature Commun. 2026, ASAP.

2）Chemoproteomic profiling reveals histone H4 dopaminylation inhibiting cell growth

Yinfeng Zhang, Yaqi Yang, Wenyan Wu, Min Zhang, Jianan Rao,Wenting Song, Yi Pan, Nan Shen, Linxue Li, Taishan Min, Kai Li, Xiaoqing Zhang, Xin-Yue Qiu,
Shu-Yu Zhang,* Wenjun Yang,* Jianye Zang,* Yu Liu, * Xi Mo*

Nature Chem. Biol. 2026, https://doi.org/10.1038/s41589-026-02225-x.

3) Ligand-Relay Strategy Enabling Copper-Catalyzed C-C/C-O/C-N Cascade Trifunctionalization of Internal Alkynes and Propargylic Sites: Synthesis of
Benzofuran-β-Lactams

Le Wang, Jie Xiao, Zi-Hao Li, Shen-Yuan Zhang, Yuan She, and Shu-Yu Zhang*
J. Am. Chem. Soc. 2026, 148, 1683.

4) Photothermal catalysis versus thermal catalysis: A palladium-catalyzed intermolecular three-component C─H 1,3-N,O-difunctionalization

He-Yuan Bai, Kai Tang, Zi-Hao Li, Xiang-Yang Chen,* and Shu-Yu Zhang*

Science Adv. 2026, 12, eaec9841.

5) Styrene-Based Axial Chiral Catalyst-Catalyzed Asymmetric Synthesis of Spirobarbiturates through Chiral Proton Shuttle

Xiao-Kun Shi, Shen-Yuan Zhang, Tian-Dong Guan, Fu-Xin Tan, Xin-Yu Chen, Yu-Ting Li, Peng-Fei Lian, Tong-Mei Ding, Shu-Yu Zhang*

ACS Catal. 2026, 16, 1533.

6) Circularly polarized luminescence with large dissymmetry factor over 10⁻¹ based on flexible point-chirality via programming at molecular level

Shi-Qiang Wei, Zi-Hao Li, Chun-Lin Sun, Yae Li, Xiao-Yu Wang, Tong-Mei Ding, Xuefeng Zhu*, Yong-Qiang Tu*, Shu-Yu Zhang*
Angew Chem. Int. Ed. 2026, 65, e23152.

7) Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging

Rui-Tian Ge, Feng Xiong, Zhen Bang Chen, Yuanjie Wang, Lin Zheng, Jia Zhou, Di Wu*, Shu-Yu Zhang*
Chem, 2025, 11, 102489.

8) Allylic C–H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system

Le Wang, Yuan She, Jie Xiao, Zi-Hao Li, Shen-Yuan Zhang, Peng-Fei Lian, Tong-Mei Ding, Shu-Yu Zhang*
Nature Commun. 2025, 16, 875.

9）Construction and Asymmetric Skeletal Rearrangement of Medium-Sized Rings: Divergent Synthesis of Pyrazole/Pyrazolone-Annulated Frameworks
Yongqiang Xu, Qing-Yun Cai, Jingping Qu, Shu-Yu Zhang*, Baomin Wang*
ACS Catal. 2025, 15, 15992.

10) Machine learning for active sites prediction of quinoline derivatives
Jie Sun, Zi-Hao Li, * Yi-Fei Yang, Shu-Yu Zhang*
Artificial Intelligence Chemistry, 2025, 100082.

11) Organocatalytic asymmetric tandem reaction for the enantioselective synthesis of chiral oxindoles to construct CyK dyes
Le Wang, Zi-Hao Li, Di Wu, Rui-Tian Ge, Jia Zhou, Yin-Feng Zhang, Shu-Yu Zhang*
Chem Catal. 2025, 5, 101188.

12) Organocatalytic Asymmetric Synthesis of Sulfonyl-Substituted Furans via a Cascade 1,6-Addition/Cyclization/Enantioselective Protonation Pathway
Peng-Fei Lian, Zi-Hao Li*, Xin-Yue Qiu, Tong-Mei Ding, Shu-Yu Zhang*
ACS Catal. 2024, 14, 12717.

13) Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone
Shi-Qiang Wei, Zi-Hao Li, Shuang-Hu Wang, Hua Chen, Xiao-Yu Wang, Yun-Zhou Gu, Ye Zhang, Hong Wang, Tong-Mei Ding, Shu-Yu Zhang,* Yong-Qiang Tu*
J. Am. Chem. Soc. 2024, 146, 18841.

14) Enantioselective sequential Michael addition/C-H olefination/Michael reaction for the efficient collective synthesis of clavine alkaloids
Zhi-Gang Ma,^† Yu Hao,^† Wei Jiang, Xian-Yu Pan, Tong-Mei Ding, Si-Hua Hou, Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2024, 102112.

15) How achiral Brønsted acid involves in co-catalyst model with chiral phosphoric acid for construction of quaternary carbon stereocenter
Zi-Hao Li,^†  Jia Zhou,^† Chang Liu, Fu-Xin Tan, Le Wang, Guo-Dong Zhu, Shu-Yu Zhang*
Chem Catal. 2024, 4, 100918.

16) Cooperative Cu/azodiformate system-catalyzed allylic C–H amination of unactivated internal alkenes directed by aminoquinoline
Le Wang, Cheng-Long Wang, Zi-Hao Li, Peng-Fei Lian, Jun-Chen Kang, Jia Zhou, Yu Hao, Ru-Xin Liu, He-Yuan Bai, Shu-Yu Zhang*
Nature Commun. 2024, 15, 1483.

17) Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Ai-Fang Wang, Jin-Miao Tian, Xiao-Jing Zhao, Zi-Hao Li, Ye Zhang, Ka Lu, Hong Wang, Shu-Yu Zhang,* Yong-Qiang Tu,* Tong-Mei Ding, Yu-Yang Xie
Angew Chem. Int. Ed. 2023, 62, e202308858.

18) Axially Chiral Styrene-Based Organocatalysts and Their Application in Asymmetric Cascade Michael/Cyclization Reaction
Yu Hao, Zi-Hao Li, Zhi-Gang Ma, Ru-Xin Liu, Rui-Tian Ge, Quan-Zhe Li, Tong-Mei Ding, and Shu-Yu Zhang*
Chem. Sci. 2023, 9496.

19) Electroreductive fluoroalkylative heteroarylationof unactivated alkenes via an unconventionalremote heteroaryl migration
Chao Chen, Shen-Yuan Zhang, Shuai-Xin Li, Zi-Hao Li, Ru-Xin Liu, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Cell Rep. Phys. Sci. 2023, 4, 101385.

20) Synthetic strategies and mechanistic studies of axially chiral styrenes
Zi-Hao Li, Quan-Zhe Li, He-Yuan Bai, Shu-Yu Zhang*
Chem Catal. 2023, 3, 100594.

21) Bioinspired Palladium-Catalyzed Intramolecular C(sp3)−H Activation for the Collective Synthesis of Proline Natural Products
Quan-Zhe Li,^† Si-Hua Hou,^† Jun-Chen Kang, Peng-Fei Lian, Yu Hao, Chao Chen, Jia Zhou, Tong-Mei Ding and Shu-Yu Zhang*
Angew Chem. Int. Ed. 2022, 61, e202207088.

22) Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
Ya Zhang#, Weizhong Chen#, Di Wu#, Yushi Liu, Zhaowei Wu, Jian Li, Shu-Yu Zhang,* and Quanjiang Ji*
Nucleic Acids Research, 2022, 50, 5948.

23) CPA-Catalyzed Enantioselective Dearomative Electrophilic Hy-drazination : Access to Chiral Aza-Quaternary Carbon Indolenines
Xin-Yue Qiu, Zi-Hao Li, Jia Zhou, Peng-Fei Lian, Li-Kun Dong, Tong-Mei Ding, He-Yuan Bai, and Shu-Yu Zhang*
ACS Catal. 2022, 12, 7511.

24) Ni-Catalyzed, Enantioselective Three-component Radical Relayed Reductive Coupling of Alkynes: Synthesis of Axially Chiral Styrenes
Quan-Zhe Li, Zi-Hao Li, Jun-Chen Kang, Tong-Mei Ding, and Shu-Yu Zhang*
Chem Catal. 2022, 2, 3185.

更多发表论文请访问：

https://orcid.org/0000-0002-1811-4159

ResearchGate

https://www.scholarmate.com/P/v2ER3e?module=pub

祝贺郑琳、陈欣宇同学顺利通过2026年度硕士论文答辩！

上海市手性药物分子工程重点实验室 副主任

《上海交通大学学报自然科学版》青年编委

《化学教育》编委

《化学反应工程与工艺》编委

2025: 教育部101计划骨干教师

2025: 上海交通大学教学成果一等奖

2023: 全国大学生化学实验创新大赛华东赛区一等奖 指导教师

2023: 上海市化学化工优秀论文一等奖 指导教师

2022: 国家教学成果一等奖(R6)

2021: 上海交通大学“教书育人奖”

2021: Thieme Chemistry Journals Award

2020: 上海交通大学“优异学士学位论文(1%)指导教师”

2019: 上海交通大学“烛光奖”

2019: 上海交通大学“优秀班主任”

2016: 上海市曙光学者

2016: 国家自然科学二等奖(R5)

2015: 教育部自然科学一等奖(R5)

2015: 国家级高层次优秀青年人才计划

本科生：致远学院《Organometallic Chemistry》

研究生：太阳集团2138登录入口《金属有机化学》、致远荣誉课程《高等有机化学》

承担本科生：大创项目、致远学者项目、莙政学者项目。

代表性教学学术研究：

1) Using Computational Chemistry to Improve Students' Multidimensional Understanding of Complex Electrophilic Aromatic Substitution Reactions: Further Analysis of the Solvent Effect, Temperature Influence, and Kinetic Behaviors
Li-Kun Dong, Zi-Hao Li, Shu-Yu Zhang*
J. Chem. Educ. 2021, 98, 3226-3236.

2) Project-Based Learning in Green Electrochemistry for Undergraduates: An Efficient Synthesis Route of Natural Product
Ru-Xin Liu, Feng Xiong, Chao Chen, Tong-Mei Ding, Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 689-696.

3) Bringing Green Organic Electrochemistry to Undergraduates: A Designed Comparison Organic Experiment of Bromination
Feng Xiong, Ru-Xin Liu, Xiao-Xuan Fan, Min Zhang, Yuan She, Wei-Qing Cao, Chao Chen, Tong-Mei Ding, and Shu-Yu Zhang*
J. Chem. Educ. 2023, 100, 4686-4695.

4) Using Computational Chemistry to Compare the Strength of Lewis Bases from HOMO Orbital Energy
Xin-Yu Chen, Zi-Hao Li,* Li-Kun Dong, Xie-Yang Jiang, and Shu-Yu Zhang*
Chin. J. Chem. Educ. 2024, 45, 38-44.

5) Stepwise or Concerted Mechanisms? Rethinking of the Classical Carbocation Rearrangement Reaction
Qing-Yun Cai, Hao Zheng, Zi-Hao Li, Li-Kun Dong, Jia Zhou, and Shu-Yu Zhang*
J. Chem. Educ. 2024, 101, 5068-5076.

课题组招生信息：

2027级博士研究生已招满，谢谢大家！

课题组开放支持本科生项目，欢迎随时联系和交流！

博士后长期招聘，提供可观薪资，申请人烦请通过email提供CV联系！